Atomic structure of the MexAB-OprM multidrug Efflux Pump from Pseudomonas aeruginosa


Nakagawa Atsushi1, Matsuura Takanori1, Akama Hiroyuki1, 2, Harada Kenichi1, Nakae Taiji2

1Institute for Protein Research, Osaka University
2The Kitasato Institute

The 5th East Asian Biophysics Symposium & the 44th Annual Meeting of the Biophysical Society of Japan (Okinawa, Japan, 2006.11.12-16)

The MexAB-OprM efflux pump of Pseudomonas aeruginosa exports structurally and funtionally diverse xenobiotics and confers a broad spectrum antibiotics resistance. This is a large problem in the therapy of hospital acuired infections. MexA and MexB are the membrane fusion protein and the transporter, respectively. OprM is assumed to form the xenobiotic exit channel across the outer membrane that collaborates with many other transporters. To investigate structure and function of the MexAB-OprM complex, we carried out X-ray crystal structure analysis of each protein components. Using the atomic structures of the each subunits, we proposed an assembly model of MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa.



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MATSUURA Takanori
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